Zoloft and marijuana

Zoloft contains the chemical substance sertraline which is a Selective Serotonin Reuptake Inhibitor (SSRI). Zoloft treats panic disorder, depression, social anxiety disorder and some other conditions. Sertraline works by balancing serotonin levels in the brain. It treats the symptoms of depression and similar conditions this way. Zoloft can cause side effects which include insomnia, dry mouth, and nausea. Zoloft is a prescription medication which is approved to treat many conditions such as depression, obsessive compulsive disorder, panic order, post-traumatic stress disorder, premenstrual dysphoric disorder and social anxiety disorder. This drug is available in tablet and liquid form. It can be taken with or without food. The age and all sorts of medical conditions determine the dosage of this medication. Sertraline can potentially interact with a number of medicines.

Marijuana is the third most widely used drug in the United States. Many physicians are recommending marijuana use for treating chronic pain, AIDS, arthritis, cancer, migraines, anorexia, seizures and glaucoma. Marijuana should not be used for recreational purposes. Dangerous risks are associated with prolonged use of marijuana. Marijuana can cause side effects. Prolonged use of marijuana can cause respiratory disease, short-term memory, drowsiness and disorientation, among other side effects it can cause.

Around five million Americans admit that they regularly use marijuana. At the same time there are also many patients who are reluctant to disclose their marijuana use to their treating physician. There is no answer for the question whether mixing Zoloft and marijuana is dangerous and whether health risk is associated with it. The American Medical Association (AMA) protests against the legalization of marijuana. It is AMA's contention that there is no evidence to support that the medical benefits of marijuana overweigh its medical risks. However, many physicians believe that marijuana has more medical benefits. The concern is about clinical developments in people who use marijuana with Zoloft.


Physicians treating the patients who smoke marijuana while taking Zoloft have observed that it will worsen the clinical depression of these patients and that it can also disrupt the brain's natural chemistry. The medical community has understood this problem, but experts in this field do not find all their patients with transparent mentality. Many patients hide their marijuana habits. This way sufficient statistical proof could not be generated. The experts feel that more medical research on this subject should be done. It is believed that cross-medication with marijuana and a drug like Zoloft can disrupt the working mechanism of Zoloft in the brain and that it can affect the brain's normal use of neurotransmitters. It is suspected that any adverse reactions due to using marijuana together with Zoloft can probably be attributed to the interaction of about 70 other cannabinioids with Zoloft, rather than the active ingredient of THC itself.

Medical experts say that it is worth noting that the adverse reactions and side effects associated with Zoloft are more than those of marijuana. Some experts feel that instead of prohibiting the use of marijuana, it is better to investigate the medical efficacy of Zoloft. The medical researches also indicate that this approach might make good sense. However, the debate on whether Zoloft and marijuana together is in any way contraindicated is still going on. The medical opinion is that it is not advisable to smoke marijuana if you have depression and social anxiety. It could worsen your condition. The effectiveness of treatment you are undergoing is reduced when you smoke marijuana. It seems there is no specific labeling about combining marijuana and Zoloft. Anyway, illicit drugs will have a potentially negative effect on your medication and on the condition being treated, in particular.

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