Zoloft interactions

Zoloft is an antidepressant having its generic name sertraline. This drug belongs to the class of Selective Serotonin Reuptake Inhibitors (SSRIs). This medicine is used worldwide. The United States Food and Drug Administration (FDA) initially approved Zoloft to treat clinical depression and later this medicine received FDA's approval to treat obsessive compulsive disorder and panic disorder. It was the first drug approved by FDA to treat post-traumatic stress disorder and subsequently it was approved to treat social anxiety disorder and pre-menstrual dysphoric disorder. The down side is that this medicine can cause severe side effects. The working mechanism of Zoloft involves balancing serotonin levels in the brain, thereby treating depression and similar conditions. The common side effects that Zoloft can cause include nausea, insomnia and dry mouth.

Zoloft can interact with other medications such as pimozide, lithium, aspirin, ibuprofen, warfarin, and linezolid. Some interactions can cause in the patients a group of symptoms known as serotonin syndrome. This can be quite dangerous. When alcohol is combined with Zoloft, it can cause unwanted side effects. Sertraline can also react with certain arrhythmia medications including propafenone, flecainide and quinidine. Zoloft can also interact with cimetidine, and disulfiram. It can react with Monoamine Oxidase Inhibitors (MAOIs) such as Phenelzine, Isocarboxazid, Selegiline, Rasagiline, and Tranylcypromine. Zoloft reacts with non-steroidal anti-inflammatory drugs such as Naproxen or naproxen sodium, Ibuprofen, Indomethacin, Diclofenac, Oxaprozin, Nabumetone, Meloxicam, Celecoxib, Ketoprofen, Etodolac, and Ketorolac.


Zoloft can interact with other SSRI or SNRI medications such as Desvenlafaxine, Citalopram, Escitalopram, Duloxetine, Fluvoxamine, Luvox, Paroxetine, Fluoxetine, Venlafaxine, and Milnacipran. Zoloft reacts with St. John's wort, tolbutamide, and tramadol. It can interact with tricyclic antidepressants such as amoxapine, amitriptyline, desipramine, clomipramine, imipramine, doxepin, nortriptyline, maprotiline, trimipramine, and protriptyline. Zoloft can react with Triptans such as almotriptan, frovatriptan, eletriptan, naratriptran, sumatriptan, zolmitriptan, and rizatriptan. Zoloft also reacts with tryptophan.

We will now discuss in detail the potentially negative interactions that Zoloft can have with other drugs as follows. The prescribing information for Zoloft states that drinking alcohol while taking Zoloft is not advisable. Combination of these two can cause unwanted side effects. Aspirin should not be taken with Zoloft as it can increase the risk of stomach bleeding. You can combine these two only after getting the consent of your doctor. Certain arrhythmia medications can increase arrhythmia medication in your blood and increase the side effects caused by Zoloft. If you combine Zoloft and cimitidine, it can increase the level of Zoloft in your blood and possibly increase the side effects of Zoloft. In this case your doctor may suggest an alternative to cimitidine or decrease your dosage of Zoloft.

Digoxin when combined with Zoloft can increase the risk of side effects with either drug. Do not take Zoloft oral concentrate, which contains 12 per cent alcohol, while taking disulfiram as it can result in severe side effects. If you take a linezolid together with Zoloft, it can cause serotonin syndrome. This syndrome includes symptoms such as hallucination, confusion, fast heartbeat, sweating, feeling faint, muscle spasm, diarrhea and walking difficulty. Combining lithium and Zoloft also causes serotonin syndrome. As serotonin syndrome is dangerous, consult your doctor before combining any of the above with Zoloft. If you combine an MAOI and Zoloft, it can cause life-threatening side effects. You should not even take them within two weeks of each other. Do not take an NSAID together with Zoloft, as it can increase the risk of stomach bleeding. Pimozide and Zoloft taken together can cause a dangerous arrhythmia condition. An SSRI or SNRI combined with Zoloft can cause serotonin syndrome. The same is the case with St. John's Wort too. When tolbutamide is combined with Zoloft, it may result in increased level of tolbutamide in your blood and possibly increase the risk of side effects.

Like the above drugs, many other drugs also can cause negative side effects when combined with Zoloft. Therefore, before starting any new medication when you are on Zoloft, talk to your doctor and follow the advices given by him/her.

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